Blar i forfatter "Krengel, Ute"

Viser treff 1-3 av 3

    • Chitinolytic enzymes contribute to the pathogenicity of Aliivibrio salmonicida LFI1238 in the invasive phase of cold-water vibriosis 

      Skåne, Anna; Edvardsen, Per Kristian Thorén; Cordara, Gabriele; Loose, Jennifer Sarah Maria; Leitl, Kira Daryl; Krengel, Ute; Sørum, Henning; Askarian, Fatemeh; Vaaje-Kolstad, Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-08)
      Background - Aliivibrio salmonicida is the causative agent of cold-water vibriosis in salmonids (Oncorhynchus mykiss and Salmo salar L.) and gadidae (Gadus morhua L.). Virulence-associated factors that are essential for the full spectrum of A. salmonicida pathogenicity are largely unknown. Chitin-active lytic polysaccharide monooxygenases (LPMOs) have been indicated to play roles in both chitin ...

    • Immunization with lytic polysaccharide monooxygenase CbpD induces protective immunity against Pseudomonas aeruginosa pneumonia 

      Askarian, Fatemeh; Tsai, Chih-Ming; Cordara, Gabriele; Zurich, Raymond H.; Bjånes, Elisabet; Golten, Ole; Sørensen, Henrik Vinther; Kousha, Armin; Meier, Angela; Chikwati, Elvis Mashingaidze; Bruun, Jack-Ansgar; Ludviksen, Judith K; Choudhury, Biswa; Trieu, Desmond; Davis, Stanley; Edvardsen, Per Kristian Thorén; Mollnes, Tom Eirik; Liu, George Y.; Krengel, Ute; Conrad, Douglas J.; Vaaje-Kolstad, Gustav; Nizet, Victor (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-17)
      Pseudomonas aeruginosa (PA) CbpD belongs to the lytic polysaccharide monooxygenases (LPMOs), a family of enzymes that cleave chitin or related polysaccharides. Here, we demonstrate a virulence role of CbpD in PA pneumonia linked to impairment of host complement function and opsonophagocytic clearance. Following intratracheal challenge, a PA ΔCbpD mutant was more easily cleared and produced less ...

    • The lytic polysaccharide monooxygenase CbpD promotes Pseudomonas aeruginosa virulence in systemic infection 

      Askarian, Fatemeh; Uchiyama, Satoshi; Masson, Helen; Sørensen, Henrik Vinther; Golten, Ole; Bunæs, Anne Cathrine; Mekasha, Sophanit; Røhr, Åsmund Kjendseth; Kommedal, Eirik Garpestad; Ludviksen, Judith Anita; Arntzen, Magnus Øverlie; Schmidt, Benjamin; Zurich, Raymond H.; Van Sorge, Nina M.; Eijsink, Vincent; Krengel, Ute; Mollnes, Tom Eirik; Lewis, Nathan E.; Nizet, Victor; Vaaje-Kolstad, Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-23)
      The recently discovered lytic polysaccharide monooxygenases (LPMOs), which cleave polysaccharides by oxidation, have been associated with bacterial virulence, but supporting functional data is scarce. Here we show that CbpD, the LPMO of <i>Pseudomonas aeruginosa</i>, is a chitin-oxidizing virulence factor that promotes survival of the bacterium in human blood. The catalytic activity of CbpD was ...